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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 51, 2021 - Issue 14
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Articles

An efficient approach to 3-thioether-functionalized 2,3-dihydrobenzofurans via a metal-free intramolecular radical cyclization/thiolation cascade reaction

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Pages 2204-2212 | Received 30 Mar 2021, Published online: 24 May 2021
 

Abstract

A diverse series of 3-thioether-functionalized 2,3-dihydrobenzofurans were prepared by an intramolecular radical cyclization/thiolation cascade reaction of alkenyl-tethered arenediazonium salts with thiophenols under transition-metal-free conditions. The mild and practical reaction conditions tolerated various functional groups and afforded the corresponding 2,3-dihydrobenzofurans in moderate to good yields.

Graphical Abstract

Acknowledgements

Our present work was financially supported by the Chemical Engineering & Technology of Zhejiang Province First-Class Discipline (Taizhou University).

Additional information

Funding

The present work was financially supported by the Chemical Engineering & Technology of Zhejiang Province First-Class Discipline (Taizhou University).

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