N-bromosuccinimide promoted synthesis of β-amino bromides under Appel reaction condition

Abstract

An efficient and facile method has been developed for the synthesis of chiral β-amino bromides from their corresponding alcohols under Appel reaction conditions. This approach allows for the deoxybromination of a variety of β-amino alcohols in excellent yields under mild conditions without any detectable racemization.

Graphical abstract

Keywords:

• N-bromosuccinimide
• N^β-protected amino alcohols
• N^β-protected amino bromides

Additional information

Funding

We thank Council of Scientific and Industrial Research (Grant No. 02(0352)/19/EMR-II), Govt. of India for the financial assistance.