Abstract
New series of thiazole derivatives were synthesized using 5-(aryldiazo)salicylaldehyde thiosemicarbazones 2a–i. Cyclocondensation of thiosemicarbazones 2a–i with chloroacetone afforded the corresponding 4-methylthiazole derivatives 3a–i. Moreover, cycloalkylation of 2a–i with ethyl bromoacetate afforded the corresponding thiazolidin-4-one derivatives 4a–i. The antimicrobial activity of the new thiazole derivatives was evaluated.
Graphical Abstract
![](/cms/asset/a797df6f-ebeb-46e7-bff6-ade991574a48/lsyc_a_1968909_uf0001_c.jpg)