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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 2
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Articles

Efficient reductions of dimethylhydrazones using preformed primary amine boranes

, , , &
Pages 185-189 | Received 15 Oct 2021, Published online: 07 Dec 2021
 

Abstract

A convenient method for the reduction of N,N-dimethylhydrazones using amine borane complexes generated in situ is described. It was found that primary amine borane complexes performed exceedingly well at reducing N,N-dimethylhydrazones in as little as 1.1 equivalents, furnishing the corresponding air-sensitive hydrazine products in excellent yields.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Generous funding for this research was provided by the National Institute for General Medical Science [GM11694].

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