Abstract
Herein, we report a Zinc catalyzed double carbonylation of aryl iodides with secondary amines under CO pressure for the synthesis of α-ketoamides in good to excellent yields. This methodology provides a simple and economic approach to derivatize useful α-ketoamides.
Graphical Abstract
Acknowledgements
The authors thank Aragen Life Sciences (Formerly known as GVK Biosciences) for providing the facilities in which this research was performed. In addition, we would like to thank Dr Somesh, Dr Satyanarayana Yennam and Dr Gajendra for their continuous support.
Supplementary data
Experimental details, characterization and copies of 1H and 13C NMR products can be found online at http://dx.doi.org/