A new approach for the synthesis of biologically active chromene compounds using a photo catalyst TiO₂-Ag

Abstract

A green and efficient method for the synthesis of chromene derivatives using TiO₂ doped Ag as a photocatalyst under visible light irradiation at room temperature is reported. The advantages of our method are clean reaction condition, easy workup procedure, use of eco-friendly solvent, and recyclable catalyst and most importantly higher yield of the product. The photocatalyst was found to be highly efficient for the synthesis of chromene derivatives within a short reaction time. The photocatalyst was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDS), and powder XRD technique and thermogravimetric analysis (TGA). In addition, the in-vitro study of helminths against S. obvelata were investigated and it was found that chromene derivatives were active against S. obvelata and showed no sign of acute toxicity in mice.

Graphical abstract

Keywords:

• Chromene
• helminths
• multi-component reactions
• nanoparticles
• photo catalyst

Acknowledgments

The authors acknowledge SAIF North-Eastern Hill University, CIF-IIT Guwahati, Department of chemistry NEHU and Department of chemistry IIT Madras for data analysis. The authors also acknowledge Dr. Geetmani Singh Nongthombam, Ching thian Moi, and Dr. Mihir Kumar Sahoo for support.

Additional information

Funding

The authors acknowledge the UGC and DST-SERB [sanctioned no.: EEQ/2016/000646] for financial support.