Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 2
155
Views
1
CrossRef citations to date
0
Altmetric
Articles

Green synthesis and antimicrobial activity of substituted diethyl (((5-(ethylthio)-1,3,4-thiadiazol-2-yl)amino)(phenyl)methyl)phosphonates

ORCID Icon, , , ORCID Icon & ORCID Icon
Pages 268-279 | Received 11 Oct 2021, Published online: 04 Jan 2022
 

Abstract

The one-pot, three-component, and facile synthesis of substituted diethyl (((5-(ethylthio)-1,3,4-thiadiazol-2-yl)amino)(phenyl)methyl)phosphonates (4a–j) has been achieved from the reaction of 2-amino-5-ethylthio-1,3,4-thiadiazole (1), various aromatic aldehydes (2a–j) and diethylphosphite (3) using Kabachnik–Fields reaction in the presence SnO2 nanoparticles as an efficient heterogeneous catalyst under solvent-free MWI condition. Furthermore, these series of new compounds were characterized by melting point, IR, NMR, and mass spectra. The newly synthesized compounds were evaluated for their antimicrobial activity which showed good activity compared to standard.

Graphical Abstract

Acknowledgments

One of the authors S. Santhisudha expresses her sincere thanks to DST, New Delhi, India, for providing support through Woman Scientist Scheme-A (WOS-A). One of the authors T. Sreekanth is thankful to the University Grants Commission (UGC), New Delhi, India for providing financial support through Senior Research Fellowship; G. Mohan acknowledges DST-PURSE 2nd Phase Programme in S.V. University, Tirupati, funded by DST, New Delhi, India for providing instrumental analysis and funding.

Additional information

Funding

The present work was financially supported by the DST, New Delhi, India through Woman Scientist Scheme-A (WOS-A) ([SR/WOS-A/CS-104/2018], dated: 14/09/2020); the University Grants Commission (UGC), New Delhi, India, through a Senior Research Fellowship.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.