Ferric metformin drug complex supported on magnetic nanofiber cellulose; An efficient access to 4-H pyrans derivatives and determination of their antimicrobial activity

Abstract

Magnetic nanofiber cellulose (NFC) was selected as a biopolymer surface for the reaction with ferric metformin and a novel nanocatalyst was prepared. This green heterogeneous organometallic catalyst was analyzed by physiochemical techniques. The new metformin drug complex supported on magnetic NFC was used as a powerful and efficient catalyst for the synthesis of functionalized 4H-pyrans derivatives. The antimicrobial activity of the products showed excellent activity against all the bacterial and fungal strains (especially compounds 7q and 6r).

Graphical Abstract

Keywords:

• Antibacterial activity
• barbituric acid
• green chemistry
• heterogenic catalyst
• metformin
• organometallic complex

Acknowledgments

The authors are thankful to Iran National Science Foundation (INSF) and Sharif University of Technology Laboratory Services Center. Thanks to Dr. Zahra Daneshfar for helping us with this project.

Disclosure statement

The authors have no conflict of interest to declare.

Additional information

Funding

This work was supported by Iran National Science Foundation (INSF) and Sharif University of Technology Laboratory Services Center.