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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 7
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Articles

Cu(OAc)2 mediated mild synthesis of 2-aminobenzimidazoles and 2-aminobenzoxazoles

Lei Hana Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, P. R. ChinaView further author information
,
LinLing Ganb Chongqing Engineering Research Center of Pharmaceutical Sciences, School of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing, P. R. ChinaView further author information
,
Xiangnan Hua Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, P. R. ChinaView further author information
,
Wei Lia Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, P. R. ChinaView further author information
,
Dali Zhua Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, P. R. ChinaView further author information
,
Jiecheng Zhenga Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, P. R. ChinaView further author information
,
Yue Wua Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, P. R. ChinaView further author information
,
Yu Yua Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, P. R. ChinaCorrespondence[email protected]
View further author information
&
Zongjie Gana Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, P. R. ChinaCorrespondence[email protected]
View further author information
 show all
Pages 1050-1058 | Received 06 Dec 2021, Published online: 22 Apr 2022
 
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Abstract

An efficient and facile synthesis for 2-aminobenzimidazoles and 2-aminobenzoxazoles has been reported. Thioureas prepared from the reaction of o-phenylenediamines or 2-aminophenols and isothiocyanate derivatives, underwent desulfurization reaction smoothly under mild conditions in the presence of Cu(OAc)2, and afforded a variety of N-heterocyclic compounds in moderate to good yields.

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Additional information

Funding

We appreciate the financial support from the National Natural Science Foundation of China [No. 21907013] and the Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJQN201900431].

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