A simple and efficient protocol for the synthesis of quinoxaline derivatives using recyclable H₅PW₆Mo₄V₂O₄₀·14H₂O catalyst

Abstract

Vanadium substituted Molybdotungstophosphoric acid (H₅PW₆Mo₄V₂O₄₀·14H₂O) was observed to be an effective solid catalyst for one-pot synthesis of several quinoxaline derivatives from the condensation reaction between various substituted o-phenylenediamine and various aromatic benzil compounds in ethanol: water (1:1) solvent under the reflux condition. The catalytic activity was tested under different reaction conditions to know the performance of the synthesized catalysts. Excellent yield, short reaction time, simple workup procedure, and reusability of the catalyst are the prominent features of our synthetic route.

Graphical Abstract

We report a series of vanadium substituted molybdotungstophosphoric acid, H₅[PW₆Mo₄V₂O₄₀]·14H₂O as a catalyst for the synthesis of quinoxaline derivatives.

Keywords:

• Catalysis
• green chemistry
• heteropoly acids
• homogeneous
• quinoxaline

Acknowledgments

The author SGS is grateful to the UGC-DST SAP for financial assistance. The author DSA gratefully acknowledges the University Grant Commission (UGC), New Delhi, for providing a senior research fellowship and the Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, India for providing a laboratory facility.