An efficient Mn-catalyzed reductive carbonylation of aryl iodides to aryl aldehydes and their benzimidazole and benzoxazoles

Abstract

The present study envisaged the development of an efficient protocol of Mn-catalyzed reductive carbonylation of aryl iodides to aryl aldehydes and their corresponding imidazole and oxazole derivatives, by using CO as a carbonyl source, in the presence of hydrosilanes and base [Na₂CO₃ and NaHCO₃ (1:1)] under mild reaction conditions gave a series of aldehydes in good yields. This approach could be extended for further functionalization of aryl aldehydes and to their corresponding benzimidazole and benzoxazole derivatives with high efficiency.

Graphical Abstract

Keywords:

• Aryl aldehydes
• aryl iodides
• carbon monoxide
• imidazole
• oxazole
• reductive carbonylation

Acknowledgements

The authors thank Aragen Life Sciences (Formerly known as GVK Biosciences) for providing the facilities in which this research was performed. In addition, we would like to thank Dr YSN and Dr Somesh Sharma for their continuous support.