Recent advances and approaches in the metal-free synthesis of 1,3-oxazole derivatives

Abstract

This review presents an overview of recent advances and approaches in the metal-free synthesis of substituted 1,3-oxazole derivatives, which will enable organic researchers to identify the challenges in synthesizing these five-membered heterocyclic compounds. Specifically, 1,3-oxazole moiety containing compounds have been reported to possess a wide variety of applications, including in the medicinal, pharmaceutical, agrochemical and material sciences sectors. We classified these nonmetal-catalyzed synthetic approaches on the basis of their starting material’s functionality that was used to synthesize 1,3-oxazole. This review covers the last six-year (2016–2021) of nonmetal catalyzed/mediated synthetic approaches.

Graphical Abstract

Keywords:

• Metal-free synthesis
• nonmetal dependent synthesis
• 1,3-oxazole derivatives

Acknowledgement

SS thanks Nandhini K.P. for the help and support.

Additional information

Funding

Rajshekhar Karpoormath would like to thank the National Research Foundation-South Africa (NRF-SA) for funding this project [Grant No. 129247]. The authors would like to thank the College of Health Science (CHS), University of KwaZulu-Natal, Durban for the financial support.