Abstract
A simple and efficient stereoselective synthesis of 10-membered Benzannulated macrolactone, Sumalactone A has been accomplished from inexpensive and commercially available starting materials. This convergent synthesis utilizes Vilsmeier-Haack formylation, Jacobsen hydrolytic kinetic resolution, esterification under Yamaguchi conditions and ring-closing metathesis as key steps.
Graphical Abstract
![](/cms/asset/31e5ec88-5d5b-45b8-a278-e329ddb5ce8a/lsyc_a_2111527_uf0001_b.jpg)
Acknowledgments
We would like to express our gratitude and thanks to Department of Chemistry, Koneru Lakshmaiah University, Guntur for constant encouragement and providing basic research facility.
Supporting information
Full experimental details, spectral data of the products, 1H NMR and 13C NMR of all the new compounds can be found via the Supplementary Content section of this article’s Web page.