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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 18
182
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Articles

Palladium(II)-catalyzed tandem reaction for the assembly of 1,3-disubstituted pyrrolo[1,2-α]pyrazines

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Pages 1788-1795 | Received 02 Jun 2022, Published online: 26 Aug 2022
 

Abstract

An efficient and simple synthesis of 1, 3-disubstituted pyrrolo[1, 2-α]pyrazines from substituted 1H-pyrrole- 2-carbonitriles and arylboronic acids was developed. It’s a palladium(II)-catalyzed cascade reaction involving C(sp)–C(sp2) coupling followed by intramolecular C–N bond formation. The method can tolerate various substrates with satisfactory yields.

Graphical Abstract

Additional information

Funding

This research was supported by Zhejiang Provincial Public Welfare Projects under Grant No. LGF22H300002 and Jinhua Science and Technology Projects under Grant No. 2021-3-005.

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