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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 18
146
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Synthetic Communications Reviews

Strategies toward the total synthesis of pretubulysin, its fragments and analogues

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Pages 1769-1787 | Received 13 May 2022, Published online: 01 Sep 2022
 

Abstract

Pretubulysin, a biosynthetic precursor of tubulysins, exhibits potent cytotoxicity in subnanomolar range toward several cancer cell lines. This natural product (extracted from myxobacterial strains) along with its derivatives plays an important role in the development of a variety of antitumor drugs. In this review, natural and synthetic pretubulysins, as well as their synthetic analogues have been discussed in detail.

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