Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 21
168
Views
1
CrossRef citations to date
0
Altmetric
Articles

Synthesis of novel 4-thiazolidinone derivatives via one-pot three-component reaction of maleimide, thiosemicarbazide, and Meldrum’s acid

, , , &
Pages 2019-2028 | Received 30 Mar 2022, Published online: 22 Sep 2022
 

Abstract

The synthesis of novel thiazolidinone derivatives via the three-component reaction has been developed involving the reaction of thiosemicarbazide with maleimide and Meldrum’s acid in a single pot. Optimization of reaction conditions was studied with different solvents and quantities of raw materials. The optimum results were obtained when the reaction was carried out in the ratio (2:2:1 mmol) of maleimide, thiosemicarbazide, and Meldrum’s acid, in the presence of two drops of triethylamine in ethanol. The products were formed with good yields with a significant decrease in reaction time. The structures of thiazolidinones were elucidated by 1H, 13C NMR, FT-IR spectroscopy, HRMS, and X-ray diffraction.

Graphical Abstract

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.