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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 23
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Articles

Selective oxidation of benzylic and allylic alcohols with PhI(OOCCF3)2/catalytic 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under mild conditions

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Pages 2198-2204 | Received 28 Jun 2022, Published online: 20 Oct 2022
 

Abstract

An effective method for selectively oxidizing benzylic and allylic alcohols, including those deactivated by electron-withdrawing groups, was described with hypervalent iodine (III)/catalytic DDQ under mild conditions. This reaction could be performed smoothly under metal-free conditions, providing green access to corresponding carbonyl compounds. The methodology may be attractive for organic synthesis and pharmaceutical chemistry.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The research Is financially supported by the CAMS Innovation Fund for Medical Sciences [CIFMS, 2021-I2M-1-054] and the Academic Promotion Programme of Shandong First Medical University [2019LJ003].

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