Synthetic protocols for non-fused pyrimidines

Abstract

Pyrimidine is the most common in nature, such as in the bases of thymine, cytosine, and uracil. Additionally, a cell’s genetic material contains it and is of utmost importance due to carefully chosen pharmacological quantities. Most of the marketed drugs contain Pyrimidine scaffold. It was, therefore, the objective of this review to congregate and evaluate the synthetic approach of various substituted non-fused pyrimidines via one-pot MCR, Microwave irradiation, green approach, and many more. The modification in the structure of pyrimidine on carbon or nitrogen atom can increase or decrease its activity. The use of several catalysts, variation of substrates, reduction in reaction time, and site selectivity are also highlighted in this review. We also demonstrated the latest progress in the synthetic approach of non-fused pyrimidine derivatives as the starting point for the pharmacological compound. The review’s objective is to provide an overview of methodologies showing the chemistry of synthesis of non-fused pyrimidines.

Graphical Abstract

Keywords:

• Acid and base catalyzed reactions
• green reagents
• multicomponent reactions
• non-catalyzed reactions
• non-fused pyrimidines

Disclosure statement

No potential conflict of interest was reported by the author(s).