Synthesis of spirocyclopropanes via iodine-promoted bimolecular cyclization of 2-benzylidene 1,3-indandiones

Abstract

A novel and efficient iodine-promoted bimolecular annulation of 2-benzylidene 1,3-indandiones has been developed. Following this protocol, a series of spirocyclopropane derivatives were furnished in good to excellent yields. The present protocol features mild conditions, short reaction time, high efficiency, good chemoselectivity and remarkable functional group tolerance.

Graphical Abstract

Keywords:

• Benzylidene indandiones
• bimolecular cyclization
• iodine
• spirocyclopropanes

Additional information

Funding

This work was supported by the Foundation of China Tobacco Anhui Industrial Corporation [2022129], the Foundation of China National Tobacco Corporation [110201903003], and the Foundation of Anhui Polytechnic University [Xjky2020079].