Mechanochemical organic synthesis in a rotary evaporator beyond conventional application: Proof-of-concept reactions

Abstract

A novel and economical process for mechanochemical organic synthesis by ball milling performed in rotary evaporator is described. The process parameters, such as molar ratio and feeding amount of reactant, rotation frequency, as well as the number, diameter and material of the milling balls, were investigated in a model reaction. Other four test reactions were then performed using this process. The results indicated that the ball milling in rotary evaporator is practical.

Graphical Abstract

Keywords:

• Ball milling
• mechanochemistry
• rotary evaporator
• solvent-free
• synthesis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the National Key Research and Development Plan (Grant No. 2017YFD0200504).