Synthetic methods for the construction of cycl[3.2.2]azine molecules

Abstract

Cycl[3.2.2]azine molecules are widely found in both synthetic chemistry and natural products. They have shown promising applications in a variety of research fields. The development of facile and stereoselective methods for the synthesis of cycl[3.2.2]azine derivatives has attracted great interests in recent years. Representative acheivements in the construction of cycl[3.2.2]azine molecules in both enantioselective and non-asymmetric fahsion are systematically reviewed.

Graphical Abstract

Kerwords:

• Benzothiazole derivatives
• cycl[3.2.2]azine molecules
• N-heterocyclic carbene
• organocatalysis

Acknowledgments

We acknowledge funding supports from Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules, Department of Education, Guizhou Province [Qianjiaohe KY number (2020)004]; Program of Introducing Talents of Discipline to Universities of China (111 Program, D20023) at Guizhou University.