One-pot protocol for the reductive amination of aldehydes using thiamine hydrochloride as a green catalyst under solvent-free condition

Abstract

A novel, green, solvent-free, and efficient method has been developed for the one-pot reductive amination of carbonyl compounds using thiamin hydrochloride as a catalyst. This method has performed reductive amination on various functionalized amines and aldehydes, including aliphatic, aromatic, and heteroaromatic ones. The reductive amination of the carbonyl compounds occurred in a single step without any side reaction. The key benefits of this technique included its easiness, greener protocol, quick transformation, variety of substrates, outstanding yield, metal-free, and catalyst recyclability. This helps to make the procedure practical, affordable, and biodegradable.

Graphical Abstract

Keywords:

• Aldehyde
• amine
• sodium borohydride
• solvent-free condition
• thiamine hydrochloride (VB₁)

Acknowledgments

The authors Shripad M Patil & Ashwini V Bedre are thankful to Principal, Dada Patil Mahavidyalaya, Karjat for giving financial support for this research work. The author Vilas B Gade is thankful to Principal, Arts, Science and Commerce College, Mokhada, Dist: Palghar for providing constant support and encouragement. Also Ravindra Bhagat thankful to the Sahebrao Shankarrao Dhamdhere Arts and Commerce College, Talegaon Dhamdhere-412208 Shirur, Pune (India).

Disclosure statement

No potential conflict was reported by the author(s).