An efficient, magnetically separable Fe₃O₄/HAp nanocomposite catalyzed one-pot synthesis of 5-alkoxycarbonyl-6-methyl-4-aryl-3,4-dihydropyrimidin-2(1H)-one derivatives

Abstract

This article describes the synthesis of iron oxide/hydroxyapatite (Fe₃O₄/HAp) nanocomposite by the hydrothermal method and utilization of Fe₃O₄/HAp as a competent, reusable, magnetically separable nano-composite catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives by cyclo-condensation of dicarbonyl compound, aryl-aldehydes and (thio)urea in EtOH:H₂O (1:1, v/v) as an eco-safe solvent. The Fe₃O₄/HAp nano-catalyst was characterized by spectral and analytical techniques such as FT-IR, SEM, XRD, EDX and VSM. The advantage of this procedure includes excellent product yield in a shorter time, a simple workup procedure, reusability of the catalyst, and avoidance of volatile organic solvent, and strong mineral acid.

Graphical Abstract

Keywords:

• Hydroxyapatite
• iron oxide nanoparticles
• biginelli reaction
• dihydropyrimidin-2(1H)-ones

Acknowledgments

The authors are thankful to the Faculty of the Department of Chemistry, Rajeshwari Vedachalam Government Arts College, Chengalpattu, Tamilnadu, India-603001.

Disclosure statement

The authors declare that there is no conflict of interest regarding the publication of this article.

Additional information

Funding

This work was not supported by any funding agency.