Recent insights into synthesis, biological activities, structure activity relationship and molecular interactions of thiazolidinone hybrids: A systematic review

Abstract

The thiazolidinone component is a specialized frame exhibiting various biological reactions comprising analgesic, hypnotic, antiviral, anticancer, antitubercular, and many more. As the target scaffold for biological investigations, current category of heterocycles has been created by researchers using a number of fundamental techniques, as well as sophisticated routes. Recent research has focused heavily on 1,3-thiazolidin-4-one heterocyclic nuclei, which contain electron configurations at the tetrahedral site and at positions 1 and 3, sulfur and nitrogen atoms, respectively. The goal of the current review is to summarize the published work concerning the chemistry and pharmacological properties of thiazolidinone derivatives over the past few years. This is executed by characterizing thiazolidinone derivatives with various pharmacological activities using structural substitution patterns around the thiazolidinone moiety as the basis for the SAR study and their interactions with various proteins. This review also summarizes current developments in the chemical, molecular and biological activities of thiazolidinones.

Graphical abstract

Keywords:

• Anti-bacterial
• anti-diabetic
• anti-microbial
• molecular interactions
• thiazolidinone