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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 54, 2024 - Issue 10
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Articles

Synthesis and biological evaluation of tetrazole ring incorporated oxazole-pyrimidine derivatives as anticancer agents

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Pages 802-814 | Received 14 Dec 2023, Published online: 07 Apr 2024
 

Abstract

A new library of tetrazole rings with oxazole-pyrimidine derivatives (9a–j) has been developed and synthesized. All of the compounds were characterized using spectral data. These were then tested for in vitro anticancer activity against four human cancer cell lines: prostate cancer (PC3 & DU-145), lung cancer (A549), and breast cancer (MCF-7) using an MTT assay. Etoposide was chosen as the positive control. Most of the compounds demonstrated moderate to good activity. These compounds (9a, 9b, 9d, 9g, and 9h) demonstrated the most powerful action. Particularly, one chemical 9h had exceptional antitumor efficacy.

Graphical Abstract

Acknowledgments

The authors are grateful to the Deanship of Scientific Research, King Khalid University for the financial support (Grant No. RGP. 2/21/44).

Declaration of interest

The authors declare that they have no competing interests.

Additional information

Funding

This work was supported by the Deanship of Scientific Research, King Khalid University (Grant No. RGP. 2/21/44).

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