KHSO₄ promoted practical synthesis of quinazolin-4(3H)-ones and benzothiadiazine 1,1-dioxides

Abstract

A broad scope of quinazolin-4(3H)-ones or benzothiadiazine 1,1-dioxides was obtained via a transition-metal free and convenient method. This approach involving KHSO₄ promoted cyclization and dehydration between diverse functionalized 2-aminobenzamides or 2-aminobenzenesulfonamides and N, N-dimethylformamide derivatives. The protocol offers moderate to excellent yields (45%-93%) under mild condition in a short of reaction time of 6 hours. The use of an environment-friendly and less expensive catalyst KHSO₄ also makes this protocol more attractive.

Graphical Abstract

Keywords:

• Quinazolin-4(3H)-ones and benzothiadiazine 1,1-dioxides
• KHSO₄
• synthesis

Acknowledgements

We appreciate the financial support from the National Natural Science Foundation of China (No. 21907013), Chongqing Talents project (No. cstc2024ycjh-bgzxm0130) and CQMU Program for Youth Innovation in Future Medicine (W0152).

Additional information

Funding

Financial support from the National Natural Science Foundation of China (No. 21907013), Chongqing Talents project (No. cstc2024ycjh-bgzxm0130) and CQMU Program for Youth Innovation in Future Medicine (W0152).