Caro's Acid–Silica Gel: An Efficient and Versatile Catalyst for the One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives

Abstract

An efficient one-pot synthesis of tetrahydrobenzo[b]pyran is described. This involved the three-component reaction of aromatic aldehydes, molononitrile, and dimedone in the presence of a catalytic amount of Caro's acid supported on silica gel in ethanol/water under reflux.

Keywords:

• Aldehydes
• dimedone
• malononitrile
• multicomponent reaction
• tetrahydrobenzo[b]pyran

ACKNOWLEDGMENT

We are grateful to Azzahra University Research Council for partial support of this work.

Notes

^a All the products were characterized by (GC-mass and IR) and comparison of melting points with those reported in the literature.

^b Yield refers to the pure isolated products.