Abstract
Modification of Beller's palladium-catalyzed cyanation procedure leads to a versatile and rapid route to poly-nitrile aromatics via easily available aryl bromides that improve on known literature methods. All cyanide ions on the iron(II) center of the nontoxic cyanide source [potassium hexacyanoferrate(II)] can be transferred to the aryl halide using palladium(II) acetate and 1,1′-bis(diphenylphosphino)ferrocen (dppf).
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Notes
a General conditions: aryl halide (1 equiv), K4[Fe(CN)6] (0.25 equiv per halide substituent), additive (1 equiv), catalyst, ligand, 10 ml solvent, 120 °C, 10 h.
b isolated yields.