Abstract
A simple and convenient protocol for the synthesis of α-diazo carbonyl compounds from the condensation of ethyl diazoacetate to aldehydes in water was developed using pyrrolidine as a catalyst.
ACKNOWLEDGMENTS
We thank the Council for Scientific and Industrial Research (CSIR) for financial support under the Task Force Project CMM-0005. L. C. thanks the CSIR, India, and T. Ramani thanks the University Grants Commission for providing a senior research fellowship.
Notes
a All reactions were carried out with 30 mol% catalyst, aldehdye (0.5 mmol), EDA (0.55 mmol), solvent (2 mL).
b Isolated yields.
a All reactions were carried out with 30 mol% catalyst, aldehdye (0.5 mmol), EDA (0.55 mmol), H2O (2 mL).
b Isolated yields.
a All reactions were carried out with 30 mol (%) catalyst, aldehyde (0.5 mmol), EDA (0.55 mmol), H2O (2 mL).
b Isolated yields.
a All reactions were carried out with 30 mol (%) catalyst, aldehyde (0.5 mmol), EDA (0.55 mmol), H2O (2 mL).
b Isolated yields.