Efficient Synthesis of 8-Methoxy-3,4-dihydro-2H-1-benzopyran-3-ol

Abstract

The article reports a practical, simple, and inexpensive procedure for the synthesis of 8-methoxy-3,4-dihydro-2H-1-benzopyran-3-ol (1). 2-Methoxy phenol on treatment offers the oxirane compound, which undergoes ring cleavage under acidic conditions to give a chlorohydrin, which on acylation and cyclization in the presence of stannic chloride followed by hydrolysis of the acetyl group, yields the desired compound (1).

Keywords:

• Benzopyranol
• 3-chromanol
• nipradilol
• vasodilator

ACKNOWLEDGMENT

The authors are thankful to the All-India Council for Technical Education, Government of India, for funding the project.