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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 2, 1972 - Issue 5
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Original Articles

A Convenient Propargylating Agent. 3-Bromo-1-Trimethylisilyl-1-Propyne

Pages 267-272 | Received 12 Jun 1972, Published online: 05 Dec 2006
 

Abstract

In the course of a synthetic approach to the Gibberellic acid skeleton,1 we desired to introduce a propargyl group by alkylation of a properly substituted cyclohexanone. Direct alkylation with propargyl bromide proved to be unsuccessful in terms of synthetic utility. Therefore a study was undertaken to investigate the introduction of a propargyl group by alkylation of a ketone. The result of this study is the subject of this communication.

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