Synthesis in the Emetine Series XV¹) Friedel-Crafts Acylation of N-Acetylhomoveratrylamine: A Facile Synthesis of 9,10-Dimethoxybenzo[a]Quinolizidine

Abstract

Benzo[a] quinolizidines are important intermediates in the synthesis of Ipecac alkaloids³ and several representatives of this class are useful therapeutic agents.^4,5,6,7,8 We would like to report a new and versatile synthesis of the known quinolizidine derivative 8 ⁹ by a procedure which can easily be extended to the preparation of analogs and homologs.¹⁰