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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 2, 1972 - Issue 6
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Original Articles

A Convenient Synthesis of Cholest-2-En-6-ONE

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Pages 357-359 | Received 17 Jul 1972, Published online: 26 Jan 2007
 

Abstract

Cholest-2-on-6-one, 3, is an important synthetic intermediate in the preparation of ecdysone and related insect moulting hormones.1–3 We report here a convenient two-step synthesis of this compound from cholesterol which combines in one step the elimination of a 36 borate ester and hydroboration-oxidation at C-6.

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