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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 3, 1973 - Issue 1
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Original Articles

Synthesis of Ethyl 6-Bromosorbate

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Pages 25-28 | Received 06 Oct 1972, Published online: 06 Dec 2006
 

Abstract

Ethyl 6-bromosorbate (1) is a useful intermediate for the preparation of Wittig and Horner-type reagents, which can be used in the synthesis of polyenes with a terminal carboxylic ester function or, as exemplified in recent syntheses of prostaglandins1,2, for the preparation of alkanoic acid derivatives. Allylic bromination of ethyl sorbate following the procedures from literature3,4,5- in our hands resulted in products containing variable amounts of the addition compound ethyl 4,5-dibromo-2-hexenoate. Isolation of pure 1 from this mixture is very difficult6.

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