The Synthesis of a Vernolepin Prototype

Abstract

The growth inhibitory sesquiterpene dilactones vernolepin, vernodalin and vernomenin¹ feature a novel angularly vinylated 2-oxa-3-decalinone functional moiety whose synthesis has been the subject of several recent reports.² We herewith describe the

culmination of model studies initiated a number of years ago,³ which have led to an efficient and facile synthesis of the prototype vinylated oxadecalinone .