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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 5, 1975 - Issue 3
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Original Articles

The Acetoxyfulvene Synthesis of Prostaglandins: A New, Versatile Synthesis of dl-PGF, dl-PGF, dl-PGE1 and dl-PGE2 from a Common Intermediate

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Pages 221-226 | Received 31 Jan 1975, Published online: 05 Dec 2006
 

Abstract

In the Corey1 synthesis of prostaglandins and in our recently published modifications2,3 a synthon containing carbon atoms 14 to 20θ is first added to a bicyclic intermediate (C-6 to C-13) and completion of the prostaglandin skeleton by addition of a second synthon containing carbon atoms 1 to 5 forms a subsequent step. In a modification4,5 of the Corey synthesis1 PGF and PGE1 were made by reversing the order in which these two synthons were added to the cyclopentane ring (C-6 to C-13). The major limitation of this modified route4,5 is that it is restricted to the preparation of prostaglandins of the 1-series, because hydrogenolysis of the benzyl group of the intermediate ester (1) reduces the C-5, C-6 double bond to form the saturated alcohol (2), which cannot be converted into prostaglandins of the 2-series.

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