The Synthesis of Spin Labeled Acetylcholine Analogs

Abstract

With the acknowledgement that spin label techniques can yield valuable information about the environment surrounding the active sites of biologically important macromolecules, e.g. receptors, several groups^1–4 have undertaken a variety of synthetic routes to develop spin labeled analogs of these important therapeutic agents. Recently, we reported the development of a spin labeled local anesthetic using the selective reducing agent, sodium cyanoborohydride. In this communication, we will discuss the synthesis of a spin labeled analog of acetylcholine and several acetylcholine type analogs.