Abstract
Halodeoxynucleosides are very useful intermediates in the synthesis of nucleoside and nucleotide derivatives. Because the iodides are more reactive,1 the corresponding chlorides have received relatively little attention although 5′-chloro-5′-deoxyadenosine (1) is effective in controlling blood pressure,2 and has been employed in a novel approach to the synthesis of polynucleotides.3 Other halonucleosides have been cited as potentially important antibiotics.1