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Abstract
Recently, the synthesis of desethermuscarine 1-3 and of two of its three possible isomers, allo– and epi– desethermuscarine, 4,5 was reported. These substances, having muscarinic activity, have shown to be extremely interesting in the study of the cholinergic receptor. As a result, the role of the ether oxygen in muscarinic activity appears to be revised. Yet, due to lack of data on the fourth isomer, a complete picture of the activity of these compounds is impossible to date.