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Abstract
The synthesis of cis-Δ4 prostaglandins has been reported.1 The conversion of these Δ4 analogs to 4,5-acetylenic prostaglandins can be accomplished via the bromination-dehydrobromination procedure reported earlier.2 A new approach to the synthesis of 4,5-acetylenic prostaglandins via readily available intermediate has been developed. We wish to report herein this general approach.3