Synthesis and Reaction of 1- and 2-Methyl-1, 3-bis (trimethylsiloxy)-1,3-butadienes. Novel Dienes for the Diels-Alder Reaction

Abstract

The Diels-Alder reaction is one of the most widely employed methods is synthetic chemistry.^1,2) The applicability of this reaction to the synthesis of useful cycloadducts is, however, rather limited.³⁾ A recent communication from our laboratory described a synthetic method for new dienes: trans-1,3-bis(trimethylsiloxy)-5-methylcyclohexa-1,3-diene (2); and illustrated their potential usefulness in the synthesis of Neotropical frog toxin (3) via Diels-Alder cycloadducts.⁴⁾