Total Synthesis of (±) Flavipucine

John A. Findlay Chemistry Department, University of New Brunswick, Fredericton, N.B., Canada, E3B 5A3

John Wah Hung Tam Chemistry Department, University of New Brunswick, Fredericton, N.B., Canada, E3B 5A3

Jiri Krepinsky Chemistry Department, University of New Brunswick, Fredericton, N.B., Canada, E3B 5A3

Abstract

In 1972 we proposed¹ structure 3 for flavipucine, an antibiotic from an Aspergillus flavipes strain. Later we reported² a novel reaction of 6-methyl-4-hydroxy-2-pyridone with α keto aldehydes which provided 1a from isobutylglyoxal and it was stated that we believed 1a would serve as a key intermediate in the total synthesis of flavipucine 3.

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Total Synthesis of (±) Flavipucine

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Total Synthesis of (±) Flavipucine

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