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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 8, 1978 - Issue 1
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Original Articles

Conjugate Addition-Decarboxylation of Magnesium Monoethyl Malonate to Enones: A Convenient One-Flask Addition of Acetate

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Pages 53-57 | Received 17 Oct 1977, Published online: 06 Dec 2006
 

Abstract

We described recently1 an improved procedure for carrying out the malonic ester synthesis whereby alkylation and decarboxylation occur in a single pot. This is accomplished by alkylating the dilithio salt of monoethyl malonic acid and then warming the resultant product.

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