Carbon-Acylation with Carboxylic-Diphenylphosphinic Anhydrides

Andrew S. Kende Department of Chemistry, University of Rochester, Rochester, New York, 14627

Dieter Scholz Department of Chemistry, University of Rochester, Rochester, New York, 14627

Josef Schneider Department of Chemistry, University of Rochester, Rochester, New York, 14627

Abstract

The reaction of carboxylic acids with chlorodiphenylphosphinite¹ in the presence of tertiary amines has been shown to yield moderately stable mixed anhydrides (I) (Equation 1) which are effective N-acylating agents in peptide synthesis. We now report the utility of such anhydrides for carbon acylation leading to ketones and acylmalonic esters.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Carbon-Acylation with Carboxylic-Diphenylphosphinic Anhydrides

Information for

Open access

Opportunities

Help and information

Carbon-Acylation with Carboxylic-Diphenylphosphinic Anhydrides

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature