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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 9, 1979 - Issue 2
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Original Articles

Fluoride-Induced Cyclisation of Silyl Ethers with Mesylates and Chlorides. A High Yield Synthesis of 0-2-Isocephems

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Pages 113-116 | Received 17 Aug 1978, Published online: 05 Dec 2006
 

Abstract

Doyle1 recently reported that conversion of benzyl ether 1a to benzo-O-2-isocephem 2a by sequential hydrogenolysis and base-induced cyclisation proceeded in 37% overall yield. We attempted a similar conversion 1b2b, which failed.

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