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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 9, 1979 - Issue 8
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Original Articles

A Facile and Convenient Method for the Synthesis of 8-Methoxy 10,11-Dihydronaphtho [1,2-b]Quinolines

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Pages 727-729 | Received 02 May 1979, Published online: 05 Dec 2006
 

Abstract

Dihydronaphthoquinolines are relatively rare polycyclic heterocyclic compounds. We wish to report a simple and convenient preparative method for hitherto unknown compounds with these new structural features. 6-methoxy tetralone1 (I) 3.5g (.02 mole) in 3 ml DMF was added slowly to 4.6g (.02 mole) of POCl3 in 3ml DMF at 0°C. The mixture was stirred for 5 hrs. and the temp. was then gradually raised from 0° to 60–65°C. The resultant complex was treated with aq. sodium acetate solution till pH5–6 was reached. The extract on usual purification, furnished 3.2g (80°%.) of 1-chloro, 6-methoxy, 1,2,3,4 tetrahydro naphthalene-2-aldehyde(II)+2

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