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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 10, 1980 - Issue 5
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Original Articles

One-Step Conversion of Aldehydes to Nitriles. Introduction of a One-Carbon Unit

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Pages 399-403 | Published online: 05 Dec 2006
 

Abstract

Among the synthetically useful applications of tosylmethyl isocyanide (TosMIC, 1) the one-step conversion of ketones to nitriles takes a prominent position. Thus far, however, the reaction, which introduces one additional carbon, has been applied to ketones only (Reaction 1).2

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