Cholinergic Compounds. XIV.¹: Synthesis of cis-2-methyl-5-dimethylaminomethyl-1,3-oxa thiolane methiodide

Abstract

In order to get information about the role of the oxygen atom in position 1 of dioxolane I and thus about the corresponding binding site of the muscarinic receptor, Elferink and Salemink² have synthesized the sulfur analog II as a cis/trans mixture in a 4:1 or 8:1 ratio, depending upon the synthetic method. This compound proved to be very active as muscarinic agent and might provide useful tool in Structure-Activity Relationship (SAR) studies on muscarinic receptor, if it were available as a pure cis form³.