Abstract
2-Phenyl-2-oxazolin-5-one (3) has been used as an intermediate in the synthesis of α-amino acids1, derivatives of α-amino acids,2 and peptides.3 Procedures for the dehydration/cyclization of hippuric acid (1) leading to the isolation of azlactone 3, have been reported using acetic anhydride,4 phosphorus trihalides5, and N, N′-dicyclohexylcarbodiimide.6 We report herein an alternative, high yield procedure utilizing a water soluble carbodiimide.