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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 10, 1980 - Issue 10
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Original Articles

Reactions at Only One of Two Equivalent Functional Groups

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Pages 767-771 | Published online: 05 Dec 2006
 

Abstract

A common problem encountered by synthetic chemists is to carry out a reaction at just one of two similar functional groups in the substrate molecule. Examples include protection/deprotection of just one hydroxyl group in a diol, addition to only one carbonyl of a diketone, etc. The problem, as depicted below, is to find conditions which maximize formation of the monoproduct (XP) while minimizing the amounts of diproduct (P2) and starting material (X2).

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